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Covalent Stabilization of a Small Molecule-RNA Complex
We demonstrate covalent bond formation between an RNA aptamer containing a cysteamine-tethered nucleobase and helix-threading peptides (HTPs) containing α-bromoacetamide N-termini. The reaction is high yielding and inhibited by a DNA strand Watson-Crick complementary to the aptamer sequence indicati...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156283/ https://ncbi.nlm.nih.gov/pubmed/21601451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.04.136 |
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