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Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions
[Image: see text] A strategy is described to design small molecules that react with their cellular RNA targets. This approach not only improves the activity of compounds targeting RNA in cell culture by ≈2500-fold but also enables cell-wide profiling of its RNA targets.
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3876275/ https://ncbi.nlm.nih.gov/pubmed/23913698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201301639 |
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