Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

Analogous to an assembly line, we employed a modular design for the high-throughput study of 1,536 structurally distinct nanoparticles with cationic cores and variable shells. This enabled elucidation of complexation, internalization, and delivery trends that could only be learned through evaluation...

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Autori principali: Siegwart, Daniel J., Whitehead, Kathryn A., Nuhn, Lutz, Sahay, Gaurav, Cheng, Hao, Jiang, Shan, Ma, Minglin, Lytton-Jean, Abigail, Vegas, Arturo, Fenton, Patrick, Levins, Christopher G., Love, Kevin T., Lee, Haeshin, Cortez, Christina, Collins, Sean P., Li, Ying Fei, Jang, Janice, Querbes, William, Zurenko, Christopher, Novobrantseva, Tatiana, Langer, Robert, Anderson, Daniel G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Physical Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156157/
https://ncbi.nlm.nih.gov/pubmed/21784981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106379108
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