Matrix remodeling stimulates stromal autophagy, “fueling” cancer cell mitochondrial metabolism and metastasis

We have previously demonstrated that loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts is a strong and independent predictor of poor clinical outcome in human breast cancer patients. However, the signaling mechanism(s) by which Cav-1 downregulation leads to this tumor-promoting mic...

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Detalhes bibliográficos
Main Authors: Castello-Cros, Remedios, Bonuccelli, Gloria, Molchansky, Alex, Capozza, Franco, Witkiewicz, Agnieszka K, Birbe, Ruth C, Howell, Anthony, Pestell, Richard G, Whitaker-Menezes, Diana, Sotgia, Federica, Lisanti, Michael P
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154420/
https://ncbi.nlm.nih.gov/pubmed/21646868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.12.16002
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