The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis

Here, we identified the milk protein α-casein as a novel suppressor of tumor growth and metastasis. Briefly, Met-1 mammary tumor cells expressing α-casein showed a ~5-fold reduction in tumor growth and a near 10-fold decrease in experimental metastasis. To identify the molecular mechanism(s), we per...

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Autores principales: Bonuccelli, Gloria, Castello-Cros, Remedios, Capozza, Franco, Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Tsirigos, Aristotelis, Xuanmao, Jiao, Whitaker-Menezes, Diana, Howell, Anthony, Lisanti, Michael P., Sotgia, Federica
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507493/
https://ncbi.nlm.nih.gov/pubmed/23047602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22227
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