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Alternative Ubiquitin Activation/Conjugation Cascades Interact with N-end rule Ubiquitin Ligases to Control Degradation of RGS Proteins

Vertebrates express two enzymes for activation of ubiquitin – UBA1, which is responsible for activation of the vast majority of E2 conjugating enzymes, and UBA6, which uses the dedicated E2, USE1. However, targets and E3s for UBA6-USE1 are unknown. Here, we demonstrate that UBA6-USE1 functions with...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lee, Peter C.W., Sowa, Mathew E., Gygi, Steven P., Harper, J. Wade
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151487/
https://ncbi.nlm.nih.gov/pubmed/21816346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.05.034
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