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Antidiabetic actions of a phosphatidylcholine ligand for nuclear receptor LRH-1
Nuclear hormone receptors regulate diverse metabolic pathways and the orphan nuclear receptor LRH-1 (NR5A2) regulates bile acid biosynthesis(1,2). Structural studies have identified phospholipids as potential LRH-1 ligands(3–5), but their functional relevance is unclear. Here we show that an unusual...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150801/ https://ncbi.nlm.nih.gov/pubmed/21614002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10111 |
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