Antidiabetic actions of a phosphatidylcholine ligand for nuclear receptor LRH-1

Nuclear hormone receptors regulate diverse metabolic pathways and the orphan nuclear receptor LRH-1 (NR5A2) regulates bile acid biosynthesis(1,2). Structural studies have identified phospholipids as potential LRH-1 ligands(3–5), but their functional relevance is unclear. Here we show that an unusual...

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Bibliographic Details
Main Authors: Lee, Jae Man, Lee, Yoon Kwang, Mamrosh, Jennifer L., Busby, Scott A., Griffin, Patrick R., Pathak, Manish C., Ortlund, Eric A., Moore, David D.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150801/
https://ncbi.nlm.nih.gov/pubmed/21614002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10111
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