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Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

BACKGROUND: Reactive microglia are associated with β-amyloid (Aβ) deposit and clearance in Alzhiemer's Disease (AD). Paradoxically, entocranial resident microglia fail to trigger an effective phagocytic response to clear Aβ deposits although they mainly exist in an "activated" state....

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書誌詳細
主要な著者: Pan, Xiao-dong, Zhu, Yuan-gui, Lin, Nan, Zhang, Jing, Ye, Qin-yong, Huang, Hua-pin, Chen, Xiao-chun
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149591/
https://ncbi.nlm.nih.gov/pubmed/21718498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-45
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