Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

BACKGROUND: Reactive microglia are associated with β-amyloid (Aβ) deposit and clearance in Alzhiemer's Disease (AD). Paradoxically, entocranial resident microglia fail to trigger an effective phagocytic response to clear Aβ deposits although they mainly exist in an "activated" state....

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Bibliographische Detailangaben
Hauptverfasser: Pan, Xiao-dong, Zhu, Yuan-gui, Lin, Nan, Zhang, Jing, Ye, Qin-yong, Huang, Hua-pin, Chen, Xiao-chun
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149591/
https://ncbi.nlm.nih.gov/pubmed/21718498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-45
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