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Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

BACKGROUND: Reactive microglia are associated with β-amyloid (Aβ) deposit and clearance in Alzhiemer's Disease (AD). Paradoxically, entocranial resident microglia fail to trigger an effective phagocytic response to clear Aβ deposits although they mainly exist in an "activated" state....

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Bibliografiske detaljer
Main Authors: Pan, Xiao-dong, Zhu, Yuan-gui, Lin, Nan, Zhang, Jing, Ye, Qin-yong, Huang, Hua-pin, Chen, Xiao-chun
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149591/
https://ncbi.nlm.nih.gov/pubmed/21718498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-45
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