Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination

Immunoglobulin class switch recombination (CSR) is initiated by double-stranded DNA breaks (DSBs) in switch regions triggered by activation-induced cytidine deaminase (AID). Although CSR correlates with epigenetic modifications at the IgH locus, the relationship between these modifications and AID r...

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Autori principali: Jeevan-Raj, Beena Patricia, Robert, Isabelle, Heyer, Vincent, Page, Adeline, Wang, Jing H., Cammas, Florence, Alt, Frederick W., Losson, Régine, Reina-San-Martin, Bernardo
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149220/
https://ncbi.nlm.nih.gov/pubmed/21746811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110118
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