Parp3 Negatively Regulates Immunoglobulin Class Switch Recombination

To generate highly specific and adapted immune responses, B cells diversify their antibody repertoire through mechanisms involving the generation of programmed DNA damage. Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by the recruitment of activation-induced cytidine...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Robert, Isabelle, Gaudot, Léa, Rogier, Mélanie, Heyer, Vincent, Noll, Aurélia, Dantzer, Françoise, Reina-San-Martin, Bernardo
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441492/
https://ncbi.nlm.nih.gov/pubmed/26000965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005240
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