Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease

We describe here the design, synthesis, molecular modeling, and biological evaluation of a series of small molecule, nonpeptide inhibitors of SARS-CoV PLpro. Our initial lead compound was identified via high-throughput screening of a diverse chemical library. We subsequently carried out structure-ac...

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Hlavní autoři: Ghosh, Arun K., Takayama, Jun, Aubin, Yoann, Ratia, Kiira, Chaudhuri, Rima, Baez, Yahira, Sleeman, Katrina, Coughlin, Melissa, Nichols, Daniel B., Mulhearn, Debbie C., Prabhakar, Bellur S., Baker, Susan C., Johnson, Michael E., Mesecar, Andrew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148848/
https://ncbi.nlm.nih.gov/pubmed/19645480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900611t
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