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A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
We report the discovery and optimization of a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). This unique protease is not only responsible for processing the viral polyprotein into its functional units but is al...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2571001/ https://ncbi.nlm.nih.gov/pubmed/18852458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805240105 |
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