A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

We report the discovery and optimization of a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). This unique protease is not only responsible for processing the viral polyprotein into its functional units but is al...

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Detalhes bibliográficos
Main Authors: Ratia, Kiira, Pegan, Scott, Takayama, Jun, Sleeman, Katrina, Coughlin, Melissa, Baliji, Surendranath, Chaudhuri, Rima, Fu, Wentao, Prabhakar, Bellur S., Johnson, Michael E., Baker, Susan C., Ghosh, Arun K., Mesecar, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571001/
https://ncbi.nlm.nih.gov/pubmed/18852458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805240105
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