Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Novel Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation

The design, synthesis, X-ray crystal structure, molecular modeling, and biological evaluation of a series of new generation SARS-CoV PLpro inhibitors are described. A new lead compound 3 (6577871) was identified via high-throughput screening of a diverse chemical library. Subsequently, we carried ou...

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Bibliografiska uppgifter
Huvudupphovsmän: Ghosh, Arun K., Takayama, Jun, Rao, Kalapala Venkateswara, Ratia, Kiira, Chaudhuri, Rima, Mulhearn, Debbie C., Lee, Hyun, Nichols, Daniel B., Baliji, Surendranath, Baker, Susan C., Johnson, Michael E., Mesecar, Andrew D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918394/
https://ncbi.nlm.nih.gov/pubmed/20527968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1004489
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