Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

The nuclear receptor pregnane X receptor (PXR) is activated by a range of xenochemicals, including chemotherapeutic drugs, and has been suggested to play a role in the development of tumor cell resistance to anticancer drugs. PXR also has been implicated as a regulator of the growth and apoptosis of...

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Main Authors: Wang, Hongwei, Venkatesh, Madhukumar, Li, Hao, Goetz, Regina, Mukherjee, Subhajit, Biswas, Arunima, Zhu, Liang, Kaubisch, Andreas, Wang, Lei, Pullman, James, Whitney, Kathleen, Kuro-o, Makoto, Roig, Andres I., Shay, Jerry W., Mohammadi, Moosa, Mani, Sridhar
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2011
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148718/
https://ncbi.nlm.nih.gov/pubmed/21747170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41514
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