Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4

The nuclear pregnane X receptor (PXR) plays a central role in regulating xenobiotic metabolism. We now report a novel role for PXR as a critical negative regulator of innate immunity after infection. Pxr(−/−) mice exhibited remarkably elevated pro-inflammatory cytokine and chemokine production follo...

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Publicado no:Sci Rep
Principais autores: Qiu, Zhijuan, Cervantes, Jorge L., Cicek, Basak B., Mukherjee, Subhajit, Venkatesh, Madhukumar, Maher, Leigh A., Salazar, Juan C., Mani, Sridhar, Khanna, Kamal M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994038/
https://ncbi.nlm.nih.gov/pubmed/27550658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31936
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