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Pharmacokinetic characterization of an RNA aptamer against osteopontin (OPN) and demonstration of in vivo efficacy in reversing growth of human breast cancer cells
INTRODUCTION: We report pharmacokinetic (PK) data, evaluation of modifications for increased stability, evaluation for cellular uptake, and mediation of regression of breast cancer for the aptamer OPN-R3. METHODS: OPN-R3 aptamer was assessed for PK data in vivo with additional comparison of IV and S...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3148491/ https://ncbi.nlm.nih.gov/pubmed/21801960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2011.05.015 |
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