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Pharmacokinetic characterization of an RNA aptamer against osteopontin (OPN) and demonstration of in vivo efficacy in reversing growth of human breast cancer cells

INTRODUCTION: We report pharmacokinetic (PK) data, evaluation of modifications for increased stability, evaluation for cellular uptake, and mediation of regression of breast cancer for the aptamer OPN-R3. METHODS: OPN-R3 aptamer was assessed for PK data in vivo with additional comparison of IV and S...

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Detalhes bibliográficos
Main Authors: Talbot, Lindsay Jones, Mi, Zhiyong, Bhattacharya, Syamal Dave, Kim, Victoria, Guo, Hongtao, Kuo, Paul C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148491/
https://ncbi.nlm.nih.gov/pubmed/21801960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2011.05.015
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