Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo()

The β-hemoglobinopathies and thalassemias are serious genetic blood disorders affecting the β-globin chain of hemoglobin A (α(2)β(A)(2)). Their clinical severity can be reduced by enhancing expression of fetal hemoglobin (γ-globin), producing HbF (α(2)γ(2,)). In studies reported here, γ-globin induc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Boosalis, Michael S., Castaneda, Serguei A., Trudel, Marie, Mabaera, Rodwell, White, Gary L., Lowrey, Christopher H., Emery, David W., Mpollo, Marthe-Sandrine Eiymo Mwa, Shen, Ling, Wargin, William A., Bohacek, Regine, Faller, Douglas V., Perrine, Susan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148318/
https://ncbi.nlm.nih.gov/pubmed/21641240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2011.04.008
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge