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Induction of Fetal Globin in β-Thalassemia: Cellular Obstacles and Molecular Progress
Accelerated apoptosis of erythroid progenitors in β-thalassemia is a significant barrier to definitive therapy because the beneficial effects of fetal globin–inducing agents on globin chain balance may not be inducible in cells in which programmed cell death is established early. Accordingly, our ob...
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| Pubblicato in: | Ann N Y Acad Sci |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4261694/ https://ncbi.nlm.nih.gov/pubmed/16339673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1196/annals.1345.033 |
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