Multiple CCR5 Conformations on the Cell Surface Are Used Differentially by Human Immunodeficiency Viruses Resistant or Sensitive to CCR5 Inhibitors

Resistance to small-molecule CCR5 inhibitors arises when HIV-1 variants acquire the ability to use inhibitor-bound CCR5 while still recognizing free CCR5. Two isolates, CC101.19 and D1/85.16, became resistant via four substitutions in the gp120 V3 region and three in the gp41 fusion peptide (FP), re...

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Bibliographic Details
Main Authors: Berro, Reem, Klasse, Per Johan, Lascano, Danny, Flegler, Ayanna, Nagashima, Kirsten A., Sanders, Rogier W., Sakmar, Thomas P., Hope, Thomas J., Moore, John P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147974/
https://ncbi.nlm.nih.gov/pubmed/21680525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00767-11
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