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CCR5 Conformations Are Dynamic and Modulated by Localization, Trafficking and G Protein Association

CCR5 acts as the principal coreceptor during HIV-1 transmission and early stages of infection. Efficient HIV-1 entry requires a series of processes, many dependent on the conformational state of both viral envelope protein and cellular receptor. Monoclonal antibodies (MAbs) are able to identify diff...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Flegler, Ayanna J., Cianci, Gianguido C., Hope, Thomas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938464/
https://ncbi.nlm.nih.gov/pubmed/24586501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089056
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