The Base Component of 3′-Azido-2′,3′-Dideoxynucleosides Influences Resistance Mutations Selected in HIV-1 Reverse Transcriptase

We recently reported that HIV-1 resistant to 3′-azido-3′-deoxythymidine (AZT) is not cross-resistant to 3′-azido-2′,3′-dideoxypurines. This finding suggested that the nucleoside base is a major determinant of HIV-1 resistance to nucleoside analogs. To further explore this hypothesis, we conducted in...

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Detalhes bibliográficos
Main Authors: Meteer, Jeffrey D., Koontz, Dianna, Asif, Ghazia, Zhang, Hong-wang, Detorio, Mervi, Solomon, Sarah, Coats, Steven J., Sluis-Cremer, Nicolas, Schinazi, Raymond F., Mellors, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147647/
https://ncbi.nlm.nih.gov/pubmed/21646480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00414-11
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