Synthesis and evaluation of 3′-azido-2′,3′-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

Based on the promising drug resistance profile and potent anti-HIV activity of β-d-3′-azido-2′,3′-dideoxyguanosine, a series of purine modified nucleosides were synthesized by a chemical transglycosylation reaction and evaluated for their antiviral activity, cytotoxicity, and intracellular metabolis...

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Hlavní autoři: Hong-wang, Zhang, Coats, Steven J., Bondada, Lavanya, Amblard, Franck, Detorio, Mervi, Asif, Ghazia, Fromentin, Emilie, Solomon, Sarah, Obikhod, Aleksandr, Whitaker, Tony, Sluis-Cremer, Nicolas, Mellors, John W., Schinazi, Raymond F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089953/
https://ncbi.nlm.nih.gov/pubmed/19948402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.11.031
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