Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3′-azido-2′,3′-dideoxyguanosine-5′-triphosphates as adenosine analogs

β-D-3′-Azido-2′,3′-dideoxyguanosine (3′-azido-ddG) is a potent inhibitor of HIV-1 replication with a superior resistance profile to zidovudine. Recently, we identified five novel 6-modified-3′-azido-ddG analogs that exhibit similar or superior anti-HIV-1 activity compared to 3′-azido-ddG in primary...

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Detalhes bibliográficos
Main Authors: Herman, Brian D., Schinazi, Raymond F., Zhang, Hong-wang, Nettles, James H., Stanton, Richard, Detorio, Mervi, Obikhod, Aleksandr, Pradère, Ugo, Coats, Steven J., Mellors, John W., Sluis-Cremer, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245946/
https://ncbi.nlm.nih.gov/pubmed/21914723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr756
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