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Molecular mechanism of HIV-1 resistance to 3’-azido-2’,3’-dideoxyguanosine

We reported that 3’-azido-2’,3’-dideoxyguanosine (3’-azido-ddG) selected for the L74V, F77L, and L214F mutations in the polymerase domain and K476N and V518I mutations in the RNase H domain of HIV-1 reverse transcriptase (RT). In this study, we have defined the molecular mechanisms of 3’-azido-ddG r...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Meteer, Jeffrey D., Schinazi, Raymond F., Mellors, John W., Sluis-Cremer, Nicolas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889670/
https://ncbi.nlm.nih.gov/pubmed/24211331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2013.10.017
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