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Molecular mechanism of HIV-1 resistance to 3’-azido-2’,3’-dideoxyguanosine
We reported that 3’-azido-2’,3’-dideoxyguanosine (3’-azido-ddG) selected for the L74V, F77L, and L214F mutations in the polymerase domain and K476N and V518I mutations in the RNase H domain of HIV-1 reverse transcriptase (RT). In this study, we have defined the molecular mechanisms of 3’-azido-ddG r...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3889670/ https://ncbi.nlm.nih.gov/pubmed/24211331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2013.10.017 |
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