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Selection of Mutations in the Connection and RNase H Domains of Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Increase Resistance to 3′-Azido-3′-Dideoxythymidine

Recent work indicates that mutations in the C-terminal domains of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) increase 3′-azido-3′-dideoxythymidine (AZT) resistance. Because it is not known whether AZT selects for mutations outside of the polymerase domain of RT, we carrie...

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Bibliografiske detaljer
Main Authors: Brehm, Jessica H., Koontz, Dianna, Meteer, Jeffrey D., Pathak, Vinay, Sluis-Cremer, Nicolas, Mellors, John W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951314/
https://ncbi.nlm.nih.gov/pubmed/17507476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02203-06
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