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Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt
PHLPP1 (PH domain leucine-rich-repeats protein phosphatase) is a Ser/Thr protein phosphatase that acts as a tumour suppressor by negatively regulating Akt. Here, we show that PHLPP1 is recruited to the cell membrane by binding to a scaffolding protein: Scribble. Knockdown of Scribble (Scrib) results...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3147256/ https://ncbi.nlm.nih.gov/pubmed/21701506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.106 |
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