Exploitation of the Ability of γ-Tocopherol to Facilitate Membrane Co-localization of Akt and PHLPP1 to Develop PHLPP1-Targeted Akt Inhibitors

Previously, we reported that Akt inactivation by γ-tocopherol (2) in PTEN-negative prostate cancer cells resulted from its unique ability to facilitate membrane co-localization of Akt and PHLPP1 (PH domain leucine-rich repeat protein phosphatase isoform 1), a Ser473-specific Akt phosphatase, through...

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Publicado en:J Med Chem
Main Authors: Yan, Ribai, Chuang, Hsiao-Ching, Kapuriya, Naval, Chou, Chih-Chien, Lai, Po-Ting, Chang, Hsin-Wen, Yang, Chia-Ning, Kulp, Samuel K., Chen, Ching-Shih
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720140/
https://ncbi.nlm.nih.gov/pubmed/25689347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501751b
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