Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines

Although the rictor-mTOR complex (mTORC2) has been shown to act as phosphoinositide-dependent kinase (PDK)2 in many cell types, other kinases have also been implicated in mediating Ser473-Akt phosphorylation. Here, we demonstrated the cell line specificity of integrin-linked kinase (ILK) versus mTOR...

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Detalhes bibliográficos
Main Authors: Lee, Su-Lin, Chou, Chih-Chien, Chuang, Hsiao-Ching, Hsu, En-Chi, Chiu, Po-Chen, Kulp, Samuel K., Byrd, John C., Chen, Ching-Shih
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686768/
https://ncbi.nlm.nih.gov/pubmed/23840605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067149
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