Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1), a major regulator of the plasmin-based pericellular proteolytic cascade, is significantly increased in human arterial plaques contributing to vessel fibrosis, arteriosclerosis and thrombosis, particularly in the context of elevated tissue TGF-β1...

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Main Authors: Samarakoon, Rohan, Chitnis, Subhanir S., Higgins, Stephen P., Higgins, Craig E., Krepinsky, Joan C., Higgins, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145778/
https://ncbi.nlm.nih.gov/pubmed/21829547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022896
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