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HIF-2α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity
HIF-2α promotes von Hippel-Lindau (VHL) deficient renal clear cell carcinoma (RCC) tumorigenesis, while HIF-1α inhibits RCC growth. As HIF-1α antagonizes c-Myc function, we hypothesized that HIF-2α might enhance c-Myc activity. We demonstrate here that HIF-2α promotes cell cycle progression in hypox...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145406/ https://ncbi.nlm.nih.gov/pubmed/17418410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.02.006 |
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