HIF-2α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity

HIF-2α promotes von Hippel-Lindau (VHL) deficient renal clear cell carcinoma (RCC) tumorigenesis, while HIF-1α inhibits RCC growth. As HIF-1α antagonizes c-Myc function, we hypothesized that HIF-2α might enhance c-Myc activity. We demonstrate here that HIF-2α promotes cell cycle progression in hypox...

Full description

Saved in:
Bibliographic Details
Main Authors: Gordan, John D., Bertovrt, Jessica A., Hu, Cheng-Jun, Diehl, J. Alan, Simon, M. Celeste
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145406/
https://ncbi.nlm.nih.gov/pubmed/17418410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.02.006
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items