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Blockade of Permeation by Potassium but Normal Gating of the G628S Nonconducting hERG Channel Mutant
G628S is a mutation in the signature sequence that forms the selectivity filter of the human ether-a-go-go-related gene (hERG) channel (GFG) and is associated with long-QT2 syndrome. G628S channels are known to have a dominant-negative effect on hERG currents, and the mutant is therefore thought to...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
The Biophysical Society
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145283/ https://ncbi.nlm.nih.gov/pubmed/21806934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.06.028 |
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