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hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state
Delayed-rectifier potassium channels (hERG and KCNQ1) play a major role in cardiac repolarization. These channels are formed by a tetrameric pore (S5–S6) surrounded by four voltage sensor domains (S1-S4). Coupling between voltage sensor domains and the pore activation gate is critical for channel vo...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5427910/ https://ncbi.nlm.nih.gov/pubmed/28273916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00155-2 |
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