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Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism
Prokaryotic Na(V) channels are tetramers and eukaryotic Na(V) channels consist of a single subunit containing four domains. Each monomer/domain contains six transmembrane segments (S1-S6), S1-S4 being the voltage-sensor domain and S5-S6 the pore domain. A crystal structure of Na(V)Ms, a prokaryotic...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125111/ https://ncbi.nlm.nih.gov/pubmed/32246066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62615-6 |
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