Increased methylation variation in epigenetic domains across cancer types

Tumor heterogeneity is a major barrier to effective cancer diagnosis and treatment. We recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon cancer, which also distinguish normal tissue types from each other, suggesting that these cDMRs might be generalized acros...

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Detalhes bibliográficos
Main Authors: Hansen, Kasper Daniel, Timp, Winston, Bravo, Héctor Corrada, Sabunciyan, Sarven, Langmead, Benjamin, McDonald, Oliver G., Wen, Bo, Wu, Hao, Liu, Yun, Diep, Dinh, Briem, Eirikur, Zhang, Kun, Irizarry, Rafael A., Feinberg, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145050/
https://ncbi.nlm.nih.gov/pubmed/21706001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.865
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