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BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions

DNA methylation is an important epigenetic modification involved in gene regulation, which can now be measured using whole-genome bisulfite sequencing. However, cost, complexity of the data, and lack of comprehensive analytical tools are major challenges that keep this technology from becoming widel...

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Autors principals: Hansen, Kasper D, Langmead, Benjamin, Irizarry, Rafael A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491411/
https://ncbi.nlm.nih.gov/pubmed/23034175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-10-r83
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