Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors

BACKGROUND: One of the most provocative recent observations in cancer epigenetics is the discovery of large hypomethylated blocks, including single copy genes, in colorectal cancer, that correspond in location to heterochromatic LOCKs (large organized chromatin lysine-modifications) and LADs (lamin-...

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Detalhes bibliográficos
Main Authors: Timp, Winston, Bravo, Hector Corrada, McDonald, Oliver G, Goggins, Michael, Umbricht, Chris, Zeiger, Martha, Feinberg, Andrew P, Irizarry, Rafael A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154522/
https://ncbi.nlm.nih.gov/pubmed/25191524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-014-0061-y
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