Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors

BACKGROUND: One of the most provocative recent observations in cancer epigenetics is the discovery of large hypomethylated blocks, including single copy genes, in colorectal cancer, that correspond in location to heterochromatic LOCKs (large organized chromatin lysine-modifications) and LADs (lamin-...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Timp, Winston, Bravo, Hector Corrada, McDonald, Oliver G, Goggins, Michael, Umbricht, Chris, Zeiger, Martha, Feinberg, Andrew P, Irizarry, Rafael A
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154522/
https://ncbi.nlm.nih.gov/pubmed/25191524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-014-0061-y
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