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Proteasome Inhibition Drives HDAC6-Dependent Recruitment of Tau to Aggresomes
Lesions containing aggregated and hyperphosphorylated tau protein are characteristic of neurodegenerative tauopathies. We have developed a cellular model of pathological tau deposition and clearance by overexpressing wild type human tau in HEK293 cells. When proteasome activity is inhibited, HEK293/...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145040/ https://ncbi.nlm.nih.gov/pubmed/21340680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-011-9502-x |
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