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SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans
Expression of human tau in Caenorhabditis elegans neurons causes accumulation of aggregated tau leading to neurodegeneration and uncoordinated movement. We used this model of human tauopathy disorders to screen for genes required for tau neurotoxicity. Recessive loss-of-function mutations in the sut...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2722225/ https://ncbi.nlm.nih.gov/pubmed/19273536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp099 |
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