DAXX/ATRX, MEN1 and mTOR Pathway Genes are Frequently Altered in Pancreatic Neuroendocrine Tumors

Pancreatic Neuroendocrine Tumors (PanNETs) are a rare but clinically important form of pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic sequences of ten non-familial PanNETs and then screened the most commonly mutated genes in 58 additional PanNETs. Remarkably,...

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Main Authors: Jiao, Yuchen, Shi, Chanjuan, Edil, Barish H., de Wilde, Roeland F., Klimstra, David S., Maitra, Anirban, Schulick, Richard D., Tang, Laura H., Wolfgang, Christopher L., Choti, Michael A., Velculescu, Victor E., Diaz, Luis A., Vogelstein, Bert, Kinzler, Kenneth W., Hruban, Ralph H., Papadopoulos, Nickolas
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144496/
https://ncbi.nlm.nih.gov/pubmed/21252315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1200609
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