Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors

Approximately 45% of sporadic well-differentiated pancreatic neuroendocrine tumors harbor mutations in either ATRX (alpha thalassemia/mental retardation X-linked) or DAXX (death domain-associated protein). These novel tumor suppressor genes encode nuclear proteins that interact with one another and...

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Main Authors: de Wilde, Roeland F, Heaphy, Christopher M, Maitra, Anirban, Meeker, Alan K, Edil, Barish H, Wolfgang, Christopher L, Ellison, Trevor A, Schulick, Richard D, Molenaar, I Quintus, Valk, Gerlof D, Vriens, Menno R, Rinkes, Inne HM Borel, Offerhaus, G Johan A, Hruban, Ralph H, Matsukuma, Karen E
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547622/
https://ncbi.nlm.nih.gov/pubmed/22575867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2012.53
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