Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation. This function of Axin is counteracted through relocalization of Axin...

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Hlavní autoři: Callow, Marinella G., Tran, Hoanh, Phu, Lilian, Lau, Ted, Lee, James, Sandoval, Wendy N., Liu, Peter S., Bheddah, Sheila, Tao, Janet, Lill, Jennie R., Hongo, Jo-Anne, Davis, David, Kirkpatrick, Donald S., Polakis, Paul, Costa, Mike
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143158/
https://ncbi.nlm.nih.gov/pubmed/21799911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022595
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