Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites

TNF-α-converting enzyme (TACE, herein denoted as Adam17) proteolytically sheds several cell-surface inflammatory proteins, but the physiologic importance of the cleavage of these substrates from leukocyte subsets during inflammation is incompletely understood. In this study, we show that Adam17-null...

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Detalhes bibliográficos
Main Authors: Tang, Jingjing, Zarbock, Alexander, Gomez, Ivan, Wilson, Carole L., Lefort, Craig T., Stadtmann, Anika, Bell, Bridgit, Huang, Li-Chuan, Ley, Klaus, Raines, Elaine W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142912/
https://ncbi.nlm.nih.gov/pubmed/21628404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-321406
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