Activation of the β globin locus by transcription factors and chromatin modifiers

Locus control regions (LCRs) alleviate chromatin-mediated transcriptional repression. Incomplete LCRs partially lose this property when integrated in transcriptionally restrictive genomic regions such as centromeres. This frequently results in position effect variegation (PEV), i.e. the suppression...

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Bibliographic Details

Published in:	EMBO J
Main Authors:	McMorrow, Tara, van den Wijngaard, Arthur, Wollenschlaeger, Alex, van de Corput, Mariëtte, Monkhorst, Kim, Trimborn, Tolleiv, Fraser, Peter, van Lohuizen, Maarten, Jenuwein, Thomas, Djabali, Malek, Philipsen, Sjaak, Grosveld, Frank, Milot, Eric
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2000
Subjects:	Articles
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314215/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10990462/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.18.4986
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