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Activation of the β globin locus by transcription factors and chromatin modifiers

Locus control regions (LCRs) alleviate chromatin-mediated transcriptional repression. Incomplete LCRs partially lose this property when integrated in transcriptionally restrictive genomic regions such as centromeres. This frequently results in position effect variegation (PEV), i.e. the suppression...

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Udgivet i:EMBO J
Principais autores: McMorrow, Tara, van den Wijngaard, Arthur, Wollenschlaeger, Alex, van de Corput, Mariëtte, Monkhorst, Kim, Trimborn, Tolleiv, Fraser, Peter, van Lohuizen, Maarten, Jenuwein, Thomas, Djabali, Malek, Philipsen, Sjaak, Grosveld, Frank, Milot, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314215/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10990462/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.18.4986
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