Functional prokaryotic–eukaryotic chimera from the pentameric ligand-gated ion channel family

Pentameric ligand-gated ion channels (pLGICs), which mediate chemo-electric signal transduction in animals, have been recently found in bacteria. Despite clear sequence and 3D structure homology, the phylogenetic distance between prokaryotic and eukaryotic homologs suggests significant structural di...

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Bibliographic Details
Main Authors: Duret, Guillaume, Van Renterghem, Catherine, Weng, Yun, Prevost, Marie, Moraga-Cid, Gustavo, Huon, Christèle, Sonner, James M., Corringer, Pierre-Jean
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141993/
https://ncbi.nlm.nih.gov/pubmed/21730130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104494108
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